The information on this site is not intended to provide medical advice. Any questions should be directed to a healthcare provider.

As of January 1, 2025, ZULRESSO® (brexanolone)
is no longer commercially available in the U.S.

What you need to know about postpartum depression

From check-ins with your healthcare provider to baby-proofing your home, you’re preparing for a lot. But there’s something you may not have prepared for: postpartum depression (PPD).


Eight moms

Approximately 1 in 8 moms report experiencing symptoms of postpartum depression

Postpartum depression is one of the most common medical conditions that can happen during or after pregnancy. But it can be hard to recognize.


Symptoms of postpartum depression

Having a baby changes your body and your life in ways that are hard to predict. Feeling exhausted, sad, moody, or tired within the first couple of weeks with your new baby can be common.

However, PPD is different. If you’re feeling depressed or you’re experiencing a lack of interest or pleasure in normal activities, these can be signs of PPD.

Below is a list of signs and symptoms commonly associated with PPD. These are not the only ones, and you do not need to have all of them to experience PPD. If you’re experiencing anything that is causing you concern, speak with your healthcare provider as soon as you can.

Mom holding baby

Signs and symptoms:

  • Persistent sad, anxious, or "empty" mood
  • Irritability
  • Trouble bonding or forming an emotional attachment with the new baby
  • Persistent doubts about the ability to care for the new baby
  • Feelings of guilt, worthlessness, hopelessness, or helplessness
  • Loss of interest or pleasure in hobbies and activities
  • Fatigue or abnormal decrease in energy
  • Difficulty concentrating, remembering, or making decisions
  • Difficulty sleeping (even when the baby is sleeping), awakening early in the morning, or oversleeping
  • Abnormal appetite, weight changes, or both
  • Thoughts about death, suicide, or harming oneself or the baby
  • Feeling restless or having trouble sitting still
  • Aches or pains, headaches, cramps, or digestive problems that do not have a clear physical cause or that do not ease even with treatment

Postpartum depression is not your fault

PPD can happen to anyone, regardless of age, ethnicity, marital status, or income. It is not a reflection of you as a mother, and it is not your fault in any way.

Mom sitting in a chair

Research shows there are some biological and environmental factors that may be associated with PPD, including:

  • Family or personal history of depression
  • Increased stressors
  • Hormone changes related to pregnancy

If you're concerned you may be experiencing PPD, speak with your healthcare provider as soon as possible.

Each Day Matters

You want to be there for your baby each and every moment, which is why it’s so important you take care of yourself, too.

Find out if there is a ZULRESSO® (brexanolone) Treating Center near you


Real moms, real stories: Learn more about the symptoms of PPD

PPD isn’t the same for everyone. Hear from women who experienced PPD to learn more about signs and symptoms.

Photo of Mom, Chelsey
Everything is just exhausting. Your everyday activities are just really stressful and hard. I would often feel like I didn’t have a place to fit. It’s hard when you’re in those moments to remember that you’re not alone.
Watch stories from real moms

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